Vascular disease - everyone's problem

Homocysteine and vascular disease.

In my experience the largest individual group of sufferers from recurrent and especially incessant pericarditis have been those without recurrent effusions who are presumed, though rarely firmly demonstrated (as here), to have an immunopathy, and especially those who are ‘steroid hooked’. Indeed, there is some evidence that corticosteroid treatment has been necessary to initiate the cycle of re...

Autophagy in vascular disease.

Autophagy is a reparative, life-sustaining process by which cytoplasmic components are sequestered in double-membrane vesicles and degraded on fusion with lysosomal compartments. Growing evidence reveals that basal autophagy is an essential in vivo process mediating proper vascular function. Moreover, autophagy is stimulated by many stress-related stimuli in the arterial wall to protect endothe...

Hypoglycemia and vascular disease.

Macrovascular and microvascular complications commonly occur in individuals with type 1 and type 2 diabetes. The mechanisms responsible for these complications remain the subjects of intense investigation. With regard to atherosclerosis specifically, there have been great strides in describing the pathophysiological connection between alterations in the diabetic metabolic state and altered endo...

Mesenteric Vascular Disease

Peripheral vascular disease.

4 T.NE S ..= v A O = TlS S ~~ ' ~TIME --3. Figure 1 Case 1. Doppler ultrasound examination of axillary arteries. (a) Left axillary artery showing diminished height of systolic wave, broadening of complex and absent negative wave as occurs in arteries beyond a stenosis indicating greater than 75% narrowing. (b) Right axillary artery with steep systolic wave and normal negative complex for compar...